Box of Kliofem used for daily menopause symptom relief

Kliofem

£21.99

Kliofem is a continuous combined HRT tablet for postmenopausal women. It relieves menopause symptoms and supports bone health with daily oestrogen and progestogen.
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Clear Start Assessment

Kliofem is a continuous combined hormone replacement therapy (HRT) used to treat symptoms of the menopause in women who have not had a period for at least 12 months. It is prescribed to relieve vasomotor symptoms such as hot flushes, night sweats, and mood changes. Kliofem is also effective in preventing postmenopausal bone loss (osteoporosis) in women at risk of fractures who cannot take other medications.

How It Works
Kliofem contains estradiol, an oestrogen, and norethisterone acetate, a progestogen. Estradiol replenishes declining oestrogen levels, which helps alleviate menopause symptoms. Norethisterone prevents the endometrial thickening caused by unopposed oestrogen in women with a uterus, reducing the risk of endometrial hyperplasia or cancer. This continuous combination allows for daily symptom control without monthly withdrawal bleeding.

Why Choose Kliofem
Kliofem is ideal for postmenopausal women seeking a once-daily HRT with consistent hormone delivery. It offers reliable symptom relief and supports bone density while minimising the risk of endometrial complications. The continuous, no-bleed regimen is preferred by many women who want a simplified HRT routine. Kliofem is well established in clinical practice and is considered a reliable option for long-term menopausal symptom management.

Important Note
This Medication is only for use by postmenopausal women and should not be used to prevent pregnancy. It must be prescribed following a full medical history and risk assessment. Kliofem is not suitable for women with a history of hormone-sensitive cancers, liver disease, or thromboembolic disorders. Regular reviews are recommended during long-term use. It is not suitable during pregnancy or breastfeeding.

Directions

Please refer to the medication’s patient information leaflet before starting any new medication.

  • Take one tablet daily at the same time each day

  • No break between packs; continue uninterrupted

  • Swallow whole with water, with or without food

  • Do not exceed the prescribed dose

  • Store below 25°C

  • Keep in original packaging

  • Keep out of reach of children

Ingredients

Active Ingredients:

  • Estradiol 2 mg

  • Norethisterone acetate 1 mg

Other Ingredients:

  • Lactose monohydrate

  • Maize starch

  • Povidone

  • Magnesium stearate

  • Hypromellose

  • Macrogol

  • Titanium dioxide

  • Red iron oxide

Side Effects

Common side effects may include:

  • Breast tenderness

  • Headache

  • Nausea

  • Abdominal cramps

  • Weight changes

Serious (rare) side effects:

  • Blood clots

  • Stroke

  • Breast or uterine cancer

  • Liver problems

  • Severe allergic reactions

Stop the medicine and seek medical attention if serious side effects occur.

Warnings

Do not take Kliofem if you have or have ever had breast cancer, blood clots, liver disease, or unexplained vaginal bleeding. Not suitable for use during pregnancy or breastfeeding. Use with caution in patients with risk factors for cardiovascular disease, diabetes, migraines, or hormone-sensitive conditions. HRT should be reviewed regularly by a healthcare provider to assess ongoing benefit and risk.

  • Kliofem is used to treat menopause symptoms such as hot flushes, night sweats, and vaginal dryness in postmenopausal women. It also helps prevent bone loss after the menopause.

  • Kliofem is suitable for postmenopausal women who have not had a period for at least 12 months and still have their womb. It’s not intended for women who are perimenopausal.

  • No, Kliofem is a continuous HRT, meaning you take the same dose daily without a break. Most women won’t experience monthly bleeding, although light spotting may occur at first.

  • If you miss a dose, take it as soon as you remember — unless more than 12 hours have passed. In that case, skip the missed tablet and continue as normal. Don’t take two tablets at once.

  • Kliofem may be used long-term, but only under medical supervision. Your doctor will review your treatment regularly to ensure the benefits of continuing outweigh any potential risks.

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